A simple, precise and reliable spectrophotometric method for the determination of Alogliptin Benzoate in pure form and pharmaceutical formulations has been developed. The method is based on the reaction of studied Alogliptin Benzoate with Bromocressol Green to form yellow colored Ion-Pair complex were extracted with chloroform in Acidic Medium pH=2, at (25 ± 0.5C). The reaction is followed spectrophotometrically by measuring the absorbance at 420 nm. Beer's law was obeyed in the range of 1.0-60.0 μg/mL with correlation coefficient 0.9995, detection limit of 0.01 μg/mL. Analytical results were adopted after processing statistically as the relative standard deviation did not exceed 1.59% and the percentage recoveries were (99.73%-100.50%).the proposed method has been applied to determine the components in commercial forms with no interference from the excipients in pharmaceutical formulations.
Al-Baath University Journal.
2020.
Determination of Alogliptin Benzoate in Pharmaceutical Forms by Extractive Spectrophotometric method
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