Dexapanthenol is one of the substances with common use in the pharmaceutical and cosmetic industries, in the pharmaceutical industries it is used in the treatment of burns, wounds and ulcers of all kinds, and is used to calm irritated skin and relieve the manifestations of redness and rashes (urticaria and atopic dermatitis).
In the cosmetic industries, dexapanthenol is included in many personal care products, including creams for skin care, preparations for treating burns, solutions for hair and skin care, in addition to shampoos and lotions.
The research included analyzing the samples of the national creams containing dexapanthenol (medicinal and cosmetic) kept at room temperature, and comparing them with the brand cream which has the same composition when opened and during use by patients by simulating the method of their use at home, and monitoring their stability during the period of use .
A set of tests were conducted on these creams to monitor their stability, which are: macroscopic, physical, chemical, and microbial tests, and the effect of the type of filling tube and the effect of the combination with vitamin E on the stability of dexapanthenol, as we found that there is no difference in quality between the creams produced By national companies (pharmaceutical or cosmetic), and that the cream packaged in a metal tube had better stability than the cream packaged in a plastic tube, and the presence of vitamin E (alpha-tocopherol) contributed to increasing the stability of dexapanthenol, and the brand cream was the best of all criteria
Finally, in use shelf life for the national cream (medicinal or cosmetic) containing dexapanthenol and kept at room temperature was determined to be 13 weeks, compared to 22 weeks for the brand cream with similar composition.
Al-Baath University Journal.
2021.
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