Simple, accurate and reliable spectrophotometric method has been developed for the quantitative determination of Cephalosporins: Cefaclor, Cefalexin, Cefadroxil in pure and pharmaceutical formulations. The method is based on the determination of that in aqueous medium pH=6.45 at 25±0.5°C.The studying spectrophotometry Cefaclor, Cefalexin, and Cefadroxil is followed by measuring the maximum absorbance at (264,261.5,262)nm. Drawing Standard Curve yield of each it. The linearity range was found to be(1-60)μg mL-1 Beer Lambert Law was best goal for concentration Cefaclor, Cefalexin, and Cefadroxil, and Correlation coefficient (R2 =0.9996, 0.9998. 0.9996).The limit of detection was(3.379, 2.825, 4.134)μg mL-1.Results of analysis were validated statistically according to Guideleness ICH (International Conference on Harmonisation). The method has been applied successfully for the estimation of Cefaclor, Cefalexin, and Cefadroxil in commercial dosage forms with no any remark of interference from the excipients.
Homs University Journal.
2015.
Determination of Some Cephalosporins in Pharmaceutical Drugs by Spectrophotometric Method