The organic reaction of indoles and benzaldehyde in the absence of organic solvents to obtain bis(Indolyl) Methanes (BIM) have been studied. The optimum reaction conditions were determined to produce (BIM). The optimal condition (catalysts, temperature and solvents) to get a high selective compounds and high yields have been studied. When use of heterogeneous catalyst (Amberlyst-15) (10%mol), tetrahydrofuran as a solvent and 65C getting a required selectivity and high yield (about 87%) in comparison to the homogeneous catalysts (H2SO4, PTSA, CH3SO3H), in addition to the low selectivity of the final product. The reaction followed by using thin layer chromatography (T.L.C), the molecular structures have determinate by spectroscopy methods :FT-IR, 1H-NMR, 13C-NMR
Chemistry and Materials Research.
2016.
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