In this paper, a compound: 3,2-dihydroxypropyl nicotate has been synthesized by Fisher Esterification reaction, The glycerol has reacted with nicotinic acid "vitamin B3" in the present of a homogeneous acid catalyst from methane sulfonic acid (CH3SO3H). After that, some physical properties of product were determined. by measuring the kinematic viscosity, turbidity and density of the aqueous solution.
After that, the biological activity of the product was studied on two types of bacteria "positive and negative gram" and compared it with a reference substance "gentamicin", the result showed that the ability of product to inhibit the growth of positive bacteria greater compared to negative once at a specific concentrations of it.
The reaction followed by using thin layer chromatography (TLC), the molecular structures have determinate by spectroscopy methods FT- IR, 1H-NMR, 13C-NMR
Al-Baath University Journal.
2021.
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