In this paper, the glycerol has reacted with indomethacin as a nonsteroidal anti-inflammatory to prepare mono-ether glycerol using appropriate conditions, basic catalyst (tert- sodium butoxide) was used with a molar ratio (1:10) (indomethacin: glycerol), a reaction time is nine hours and a temperature of reaction 100°C the product was obtained with high selectivity and high yield (68%). After that, some physical properties of the reaction product were determined by measuring the kinematic viscosity, turbidity and density and amount of deflection of the polarized light.
The reaction followed by using thin layer chromatography (TLC), then the product was separated and purified, the molecular structures have determinate by spectroscopy methods FT- IR, 1H-NMR, 13C-NMR
Al-baath University Journal.
2021.
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