In this paper, the glycerol has reacted with chlorpheniramine as a nonsteroidal anti-inflammatory to prepare mono-ether glycerol using appropriate conditions, basic catalyst (tert- sodium butoxide) was used with a molar ratio (1:10) (chlorpheniramine: glycerol), a reaction time is nine hours and a temperature of reaction 100°C the product was obtained with high selectivity and high yield (58%). After that, some physical and biological properties of the reaction product were determined by measuring the kinematic viscosity, turbidity and density and amount of deflection of the polarized light, In addition to the biological properties.
The reaction followed by using thin layer chromatography (T.L.C), then the product was separated and purified, the molecular structures have determinate by spectroscopy methods FT- IR, 1H-NMR, 13C-NMR.
Al-Baath University Journal.
2022.
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