In this paper, the chemical structure of pectin has been modified by reacting of carboxyl group in pectin with tetrabutyl ammonium hydroxide [TBA-OH], (acid-base) reaction, to change hydrophilic properties by adding hydrophobic alkyl chains to the polymer chain in pectin, Some physical properties of both: pectin and tetrabutyl ammonium pectin; has been determined by measuring the Kinematic viscosity, degree of turbidity and density of their water solutions at different concentration.
Finally, the kinetic of drug release "aspirin" has been studied by comparing the time of release by loading the drug substance in both of pectin and tetrabutyl ammonium pectin forming beads in a salty water media. The results showed an increase in the release time of the drug by increasing the hydrophobic characteristics of the modified pectin with alkyl chains "tetrabutyl ammonium [TBA[ ".
The structures have been determined by spectroscopic methods: FT-IR, 1H-NMR.
Al-Baath University Journal.
2018.
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