The antibacterial activity of silver nanoparticles (AgNPs) has been evaluated using the broth microdilution method against bacterial strains of Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 8739). The results show that AgNPs have an antibacterial activity against S. aureus, with a minimum inhibitory concentration (MIC) of 2.5 μg/mL and a minimum bactericidal concentration (MBC) of 10 μg/mL, and demonstrate antibacterial activity against E. coli, with a MIC of 1.25 μg/mL and a MBC of 2.5 μg/mL. The cytotoxicity effect of AgNPs on red blood cells (RBC) was evaluated using a human blood sample, as both MIC and MBC concentrations against Staphylococcus aureus and Escherichia coli showed no hemolytic effect. This result could be useful for applications in the pharmaceutical industry as an alternative to antibiotics.
Al-Baath University Journal.
2022.
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