Batch-to-batch consistency is one of the characteristics of good medicines. This consistency is evaluated by technological and chemical properties i.e uniformity of content and dissolution rate that provides a good absorption and eventually attended therapeutic effect. During the years of war, the quality of many pharmaceutical products were affected and there were difficulties in purchasing either active pharmaceutical ingredient or excipients. Moreover, some companies has stopped their production for some periods. In this study we were concerned by two classes of medicines to evaluate how much their quality was affected during the last years, Metformine 850 mg as non modified-release tablet indicated for diabetes and indomethacine capsule 25 mg used as non steroid anti inflammatory drugs.
In this study we could assess nine batches of metformine from three pharmaceutical companies during the last three years while there was a difficulty in acquiring different batches of indomethacine so we could just tested three batches which belong to one company. Tests were carried out relying on pharmacopoeia monographs especially dissolution test of metformine and dissolution rate of indomethacine.
We found that all batches are equivalent in vitro since the Q values which represented the quantity released from administerd dose were more than 85% and 90% for metformine and indomethacine respectively. This study could confirm that the locally marketed medicines are good enough to be exchanged by pharmacists if there is a need. Moreover, we could conclude that pharmaceutical industry and quality control still keep a good surveillance in spite of the different effect of crise on the different economic aspects.
Homs University Journal.
2018.