Antibiotic resistance is one of the world’s maximum urgent public healthcare problems. Silver nanoparticles (AgNPs) are appealing alternative due to the fact they may be non-poisonous to the human frame at low concentrations and feature antibacterial actions. The present study aimed to biosynthesis of silver nanoparticles (AgNPs) extracellularly using Aspergillus niger extracts and to evaluate their antibacterial activity. The biosynthesized AgNPs were characterized by UV-Vis, FT-IR, SEM, and EDX. Furthermore, antibacterial activity was evaluated against bacterial strains of Staphylococcus aureus (ATCC 6538, Gram-positive) and Escherichia coli (ATCC 8739, Gram-negative) through the well diffusion method. The results confirmed that the synthesized AgNPs were spherical and their dimensions were less than 100 nm. AgNPs revealed a good antibacterial activity (for 20 μg/ml) against E. coli and exhibited an excellent synergistic effect against S. aureus when combined with vancomycin. The current research had concluded that AgNPs have the potential to be an alternative or partner to antibiotics to control microbial infections caused by multidrug-resistant (MDR) pathogens.
Bulletin of Pharmaceutical Sciences - Assiut.
2022.
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