Some pain relievers and non-steroidal Anti-Inflammatory drugs (NSAIDs) were identified simultaneously: Diphenhydramine Hydrochloride (DMH), Sodium Diclofenac (SD), pure state Mefenamic Acid (MA)and wastewater from the pharmaceutical industry using High-Performance Liquid Phase Chromatography inverted RP-HPLC. The proposed method was characterized by good accuracy and health. The proposed method was used to investigate the low concentrations of studied substances produced in the national pharmaceutical industrial facilities and the most productive of such compounds. This study was conducted on different samples of industrial wastewater and sewage at the most important local laboratories and pharmaceutical establishments, in Syria. The results of the analytical study were excellent. It affects both the environment and the human being. Although Very low concentrations of (DH, DS, MA) were identified in the pharmaceutical waste water samples using RP-HPLC technology. The proposed analytical method achieved high accuracy and sensitivity, with Excellent detection limits.
Journal of Pharmaceutics and Drug Research.
2020.