In this paper, the chemical structure of chitosan has been modified by trans esterification reaction with methyl esters both of octanoic and dodecanoic acid, using potassium carbonate as a based catalyst, the degree of substitution has been determinated to change hydrophilic properties, Some physical properties of trans esterification products has been determined by measuring the Kinematic viscosity, degree of turbidity and density of their water solutions.
Finally, the kinetic study of Pharmaceutical substance "aspirin" has been studying by comparing the time of release by loading the drug substance forming beads in a salty water media. The result of the study showed an increase in the release time of the drug substance by increasing the hydrophobic characteristics of the modified ketosan With alkyl chains "C8, C12". The molecular structures have determinate by spectroscopy methods: FT-IR, 1H-NMR.
Al-Baath University Journal.
2017.
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