In this work we investigated the ability of using polystyrene (PST) as a matrix for Drug Selective Membrane, also incorporating two ion pairs in the same selective electrode's membrane, and so constructing an electrode sensitive to either Ciprofloxacin (CFX) or Tinidazole (TZL) according to the standard filling solution of the electrode, subsequently determine the two drugs CFX and TZL Simultaneously in their combined solutions, 3 polystyrene membrane drug selective sensors were constructed for CFX and TZL analysis intended. The electro active materials were CFX- phosphomolybdic acid (CFX-PMA), TZL- phosphomolybdic acid (TZL-PMA) and a composition of CFX-PMA+TZL-PMA. The characterization and analytical properties were determined, and the casting selective membranes of the selective electrodes were plasticized by di-n-butyl phthalate (DBP). Each of the assembled electrodes have internal reference Ag/AgCl electrode. Also, the gathered sensors have external reference Ag/AgCl electrode. The developed sensors showed near NERNSTIAN response for ion pair percentages of 7% for both CFX-PMA, TZL-PMA. The electrodes showed a rapid responses of 11-13 sec for a period of 16-17 days, with no changes that have meaningful results in the electrodes parameters. The suggested sensors have a measurement pH ranges 2.0-6.0 for CFX, and 2.0-5.0 for TZL without using any buffer. The sensors were used as indicator electrodes for direct determination of CFX and TZL in pharmaceutical preparations with mean relative standard deviation less than 2% that indicating good precision, as well as in pure form solutions with average recovery of 99.97%, 100.02% and 99.93% (CFX) or 99.97% (TZL) and a mean relative standard deviation of 0.03%, 0.05% and 0.11% (CFX) or 0.03% (TZL)% at 1 mM (367.8 µg/mL CFX, or 247.3 µg/mL TZL) for CFX-PMA, TZL-PMA, and CFX-PMA+TZL-PMA sensors respectively.
Research Journal of Pharmacy and Technology.
2019.
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