The free iodine (I2) in povidone-iodine (PVP-I) solutions is responsible for its bactericidal activity. The USP establishes values for iodine content in PVP-I solutions. It is extremly important to verify whether the concentration of such solutions fits the values established by USP. The aim of the present work was to determine the active pharmaceutical ingredient of samples of PVP-I solutions, which were obtained from market in Syria (A, B, C) for PVP-I 10%, (G, H, I, J) for PVP-I 4% foam solution and 3 different patches for each one and one solution produced by Mundipharma foreign Company (Betadine® 10% topical solution), which used as a reference. The research included control of pH solutions, free iodine concentration and evaluation of bactericidal activity by using disc diffusion method and rapidity of the bactericidal activity on both Staphylococcus aureus and Escherichia coli in the last year of validity. For PVP-I 10% topical solution, sample (A) was the closest to Betadine 10% topical solution, which had the highest level. Study revealed significant difference between local companies, where (A) had the best bactericidal effect. The percentage of iodine in (B, C) solutions were less than the required range. For PVP-I 4% foam solution, the sample (H) was the closest to sample (G), which had the highest level. Study revealed significant difference between local companies, where (G, H) had the best bactericidal effect. The percentage of iodine in (I, J) solutions were less than the required range. pH values of solutions were within the range of activity and stability. The high level of free iodine was accompanied with an increase of inhibition diameter and rapidity of bactericidal activity.
Homs University Journal.
2019.
Quality Control of Some Povidone-Iodine Products Locally Marketed in Syria