We investigated the capability of putting3 ion complex (pairs) in the same selective electrode's membrane, and so constructing an electrode sensitive to either Ciprofloxacin (CFX), Metronidazole (MZL), or Minocycline (MIN) according to the standard filling solution of the electrode, subsequently determine the three drugs CFX, MZL, and MIN Simultaneously in their combined solutions.Four PVC membrane drug selective sensors were constructed forCFX, MZL, and MINanalysis intended. The electroactive materials wereCFX- Tetraphenyl borate (CFX-TPB), MZL-Tetraphenyl borate (MZL-TPB), MIN-Tetraphenyl borate (MIN-TPB), and a composition of CFXTPB +MZL-TPB + MIN-TPB. The characterization and analytical properties were determined,and the casting selective membranes of the selective electrodes were plasticized by Dioctylphthalate (DOP). Each of the assembled electrodes haveinternal reference Ag/AgCl electrode. Also, the gathered sensors haveexternal reference Ag/AgCl electrode. The developed sensors showed near NERNSTIAN response for ion pair percentagesof7%for both CFX-TPB andMZL-TPB, and 6% for MIN-TPB.The electrodes demonstrated a rapid responses of 9-14 sec for a period of 14-17days, with no changes that have meaningful results in the electrodes parameters. The suggested sensors have measurement pH ranges 2.0-6.0 for CFX, 2.0-5.25 for MZL, and 2.0-5.0 for MIN without using any buffers. The sensors were used asindicator electrodes for direct determination of CFX, MZL, and MIN in pharmaceutical preparations with mean relative standard deviation less than 2% that indicating good precision, as well as in pure form solutions with average recovery of 99.99, 99.94, 99.98 and 99.85% (CFX) or 99.86% (MZL) or 99.99% (MIN) and a mean relative standard deviation of 0.04%, 0.14%, 0.02 and 0.08% (CFX) or 0.20% (MZL)% or 0.02% (MIN) at 1 mM (367.8 μg/mL CFX, 171.2 μg/mL MZL, or 493.9 μg/mL MIN) for SENSOR-1, SENSOR-2, SENSOR-3, SENSOR-4, respectively. The acquire results were within the acceptance range of less than 2.0 % of RSD % for precision and more than 99.18 % of R % for the accuracy. ForCFX-TPB + MZL-TPB + MIN-TPB sensors respectively.
Journal of Global Trends in Pharmaceutical Sciences
2020.
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